A heightened threat of unique malformations with codeine publicity for instance respiratory malformations, spina bifida and congenital coronary heart defects have been documented in a few scientific studies.

Codeine has minimal plasma protein binding with about seven to twenty five% of codeine sure to plasma proteins. Codeine passes the blood Mind barrier and also the placental barrier. Small amounts of codeine and its metabolite, morphine, are transferred to human breast milk.

Steer clear of the usage of Promethazine HCl and Codeine Phosphate Oral Alternative in adolescents 12 to 18 a long time of age who have other hazard factors which could boost their sensitivity towards the respiratory depressant consequences of codeine.

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Codeine: In individuals acquiring MAO inhibitors, an First tiny take a look at dose is advisable to allow observation of any extreme narcotic outcomes or MAOI interaction.

are Expecting or strategy to be Expecting. Promethazine Hydrochloride and Codeine Phosphate Oral Solution can hurt your unborn infant. See “What exactly is A very powerful information I really should learn about Promethazine Hydrochloride and Codeine Phosphate Oral Option?” are breastfeeding or decide to breastfeed. Codeine passes into your breast milk and might cause serious Negative effects inside your baby like greater sleepiness, respiratory issues (respiratory depression), and Loss of life. It's not necessarily recognised if promethazine can go into your breast milk.

g., amiodarone, quinidine) may result in an increase in codeine plasma concentrations in addition to a lower in Energetic metabolite morphine plasma check here concentration which could bring about an analgesic efficacy reduction or signs or symptoms of opioid withdrawal.

The opioid antagonists, naloxone and nalmefene, are certain antidotes for respiratory despair resulting from opioid overdose. For clinically major respiratory or circulatory despair secondary to codeine overdose, administer an opioid antagonist. An antagonist should not be administered while in the absence of clinically sizeable respiratory depression. Because website the length of opioid reversal is anticipated being under the length of motion of codeine in Promethazine HCl and Codeine Phosphate Oral Solution, very carefully keep an eye on the affected individual till spontaneous respiration is reliably reestablished.

The complex storage or entry is needed for the respectable reason of storing Choices that aren't asked for with the subscriber or consumer. Figures Statistics

Medical studies of promethazine hydrochloride and codeine phosphate syrup did not contain ample numbers of topics aged sixty five and more than to determine whether or not they react in another website way from more youthful topics. Other documented scientific practical experience has not recognized discrepancies in responses amongst the aged and younger patients.

Stimulation may very well be evident, especially in youngsters and geriatric sufferers. Convulsions may possibly almost never happen. A paradoxical reaction has been noted in children receiving single doses of 75 mg to one hundred twenty five mg orally, characterised by hyperexcitability and nightmares.

Promethazine should be made use of cautiously in individuals with heart problems or with impairment of liver functionality.

Codeine and its salts are very well absorbed following the two oral and parenteral administration. Codeine is about two/three as helpful orally check here as parenterally. Codeine is metabolized mainly while in the get more info liver by enzymes with the endoplasmic reticulum, where it undergoes O-demethylation, N-demethylation, and partial conjugation with glucuronic acid.

長期使用時，身體可對可待因產生耐藥性，令藥效減弱，並有可能產生依賴性。